Pathological Digital Biomarkers: Validation and Application

construction and validation of translation metacognitive strategy questionnaire and its application to translation quality

like any other learning activity, translation is a problem solving activity which involves executing parallel cognitive processes. the ability to think about these higher processes, plan, organize, monitor and evaluate the most influential executive cognitive processes is what flavell (1975) called “metacognition” which encompasses raising awareness of mental processes as well as using effectiv...

Discovery and validation of biomarkers based on computational models of normal and pathological hippocampal rhythms

Quantitative systems pharmacology is an emerging field with the goal of offering new methodologies for drug discovery based on concepts that grew out of systems theory. Oscillation is a central topic of dynamical systems theory, and neural oscillations are related to both normal and pathological behavior. The role of abnormal neural oscillation in several dynamical diseases is briefly reviewed....

Biomarkers for pancreatic cancer - - Identification through meta - analysis and validation on tissue microarrays utilizing digital pathology for potential clinical application

Digital Roentgen Stereophotogrammetry : Development , Validation , and Clinical Application

Contents 1 General introduction 9 2 RSA in practical steps 19 3 RSA of the Mallory-Head femoral stem without attached markers 33 4 Roentgen stereophotogrammetric analysis of metal-backed hemispherical cups without attached markers 49 5 Fast and accurate automated measurements in digitised stereophotogrammetric radiographs 59 6 Digital automated RSA compared to manually operated RSA 75 7 Model-b...

Digital detection of biomarkers assisted by nanoparticles: application to diagnostics.

Single-molecule detection and counting is the new frontier in biomarker analysis. Here, we report on recent techniques for the digital detection of biomolecules for clinical application. First we highlight methods based on the immunocapture of proteins onto microparticles, followed by isolation of individual particles in microenvironments so that a sufficient signal is acquired for each binding...